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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted

Additionally, chronic GLP1 or GLP1 mimetic administration to human diabetic subjects was associated with improvements in glycaemic control and a modest 1.55.3 kg weight loss over a period of 0.53 years (Klonoff et al., 2008

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Can GLP-1 medications affect the diaphragm

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